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This surname, with the Isaacs, Isaacson, Isaac and Isacke, may be of English, French or Jewish origin, and derives from the male "Yitschak", a derivative of "tsachak", to laugh. This name was given to the son of Abraham and Sarah, and popular etymology connects the meaning with Sarah's laughter and her joy at bearing a son in her old age. The translators of the Old Testament rendered "Yitschak" as "Isaak"; it was then into Isaac. Though popular among Eastern Christians, it occurs only twice in the period as the name of a priest. "Isac" (without surname) appears in the book of 1086, and "Ysaac" (a member of the Jewish community) was noted in "Muniments of Magdalen College", Oxford, dated 1207.

List Ancestral records for:- Isacke

Early examples of the surname include: Henry Isaac (Worcestershire, 1275) and Walter Isak (Somerset, 1327). A granted to the Isaac family of Devonshire in the reign of Henry 111 (1216 - 1272) is a divided per and purple with a cross flory. The first recorded spelling of the family name is shown to be that of Johannes Isaak, which was dated 1273, in the " of Norfolk", during the reign of King Edward 1, known as "", 1272 - 1307. Surnames became necessary when governments introduced personal taxation. In England this was known as . Throughout the centuries, surnames in every country have continued to "develop" often leading to astonishing variants of the original spelling.
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