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This interesting surname is of Scottish origin, and is a of the male Isaac, itself coming from the "Yitschak", a derivative of "tsachak", to laugh. This name was given to the son of Abraham and Sarah, and popular etymology connects the meaning with Sarah's laughter in her joy at bearing a son in her old age. The translators of the Old Testament rendered "Yitschak" as "Isaak"; it was then into "Isaac". Though popular among Eastern Christians, it occurs only twice in the period as the name of a priest. "Isac" (without surname) occurs in the Book of 1086, and Isaac was the name borne by the prior of Scone in 1154, while Ysaac of Brechin was a at St. Andrew's, Scotland, circa 1178. The patronymic form of the name appears in the early 13th Century (see below), the "" meaning "son of".

List Ancestral records for:- McIsaac

In the province of the name is variously spelt MacKissock and MacKissack. On March 27th 1732, a daughter, Mary, was born to Neil McIsaac and Mary McClean, in Edinburgh, Midlothian. The first recorded spelling of the family name is shown to be that of Gillandes Macysac, which was dated 1231, a charter witness, in the "Charters of the of Beauly", Inverness-shire, Scotland, during the reign of King Alexander 11 of Scotland, 1214 - 1249. Surnames became necessary when governments introduced personal taxation. In England this was known as . Throughout the centuries, surnames in every country have continued to "develop" often leading to astonishing of the original spelling.
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